Individual Participant Data (IPD) Sharing Statement:ĭeidentified data will be shared in a manner TBD based on funding availability and journal requirements.īeginning 12 months and ending 3 years following article publication. Nathaniel Schuster, Assistant Profesor, University of California, San Diego The study pharmacist will place the drug capsules in identical sealed plastic bags labeled "Treatment 1" through "Treatment 3".Įffect of Gabapentin and Tizanidine on Insomnia in Chronic Pain Patients: A Randomized, Double-blind, Placebo-controlled Crossover Trial. The 3 treatments will be identically encapsulated by the study pharmacist. #CGRONIC PAIN SEVERE INSOMNIA HELP GENERATOR#Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Įach participant will have an identification number and randomization of drug sequence allocation will be performed a priori using a random number generator by the study pharmacist. #CGRONIC PAIN SEVERE INSOMNIA HELP TRIAL#Randomized, Double-bind, Placebo-controlled, Crossover Trial Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Our hypothesis is that gabapentin and tizanidine will both be more effective than placebo in alleviating insomnia in chronic pain patients but will not be different from one another. Monday-Thursday nights) will serve as a 4-day washout period between treatments. Scores on the Monday preceding the first treatment will serve as baseline and the period between treatments (i.e. Patients will also monitor their sleepiness, pain relief and overall improvement as secondary variants using the Stanford Sleepiness Scale (SSS), Visual Analog Scale (VAS), and Patient's Global Impression of Change (PGIC) questionnaires respectively. The primary outcome consists of the difference in mean AIS scores between the 3 treatments at the primary time point, which is Monday of each week (after 3 nights of drug intake). In each week, patients will receive 3-night (Friday-Sunday) trials each of placebo, gabapentin or tizanidine in a randomized, double-blind order and will monitor their insomnia using the Athens Insomnia Scale (AIS) questionnaire (adapted to fit the time frame of this trial). In this double-blind, placebo-controlled, randomized, crossover trial, gabapentin and tizanidine, two drugs which are respectively commonly used to treat neuropathic and musculoskeletal pain, will be compared to each other and to placebo in their ability to alleviate insomnia in chronic pain patients. Identifying medication that alleviates pain and insomnia simultaneously may help reduce risks associated with polypharmacy, including drug-drug interactions. Importantly, these two conditions frequently co-occur, with 50-80% of chronic pain patients reporting sleep disturbances.
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It sought to have the Electoral Court’s decision set aside on the basis that the IEC was not obliged to record voters’ addresses and that the elections must be proceeded with on the voters’ roll as it currently stands without addresses. Aggrieved by the outcome, the IEC approached the Constitutional Court. That Court insisted on the recordal of voters’ addresses, where available, and postponed the by-elections for six weeks. On this ground, they successfully challenged the validity of the voters’ roll and sought the postponement of the impending by-elections in the Electoral Court. When the independent candidates examined the voters’ roll, they discovered that some voters’ addresses were still not recorded. The Tlokwe by-elections were re-scheduled for 24 February 2016. It effectively ordered the IEC to compile a voters’ roll that had available voters’ addresses, for purposes of future elections and by-elections. On 30 November 2015, the Constitutional Court found that electoral irregularities had been committed in Tlokwe and set aside the outcome of the by-elections. Independent candidates that had lost by-elections held in the Tlokwe Local Municipality in 2013 challenged the freeness and fairness of those elections on the basis that voters’ addresses were not recorded and many people were registered in wrong voting districts. If so, from when are they to be recorded? And if they are unable to correct the voters’ roll before the elections are held, should the elections be postponed or proceeded with even if the voters’ roll is defective? Today the Constitutional Court handed down judgment on whether the Electoral Commission (IEC) is required to have a national common voters’ roll that has the addresses of registered voters for the purposes of the August 2016 local government elections.
We are even sure you will have a better connection using different protocols. Shadowsocks X supports both Socks5 protocol and Http Proxy,if you want to enable Http Proxy for those softwares that don't support socks5,you can enable this in Preferences,for example,if you want to use it in Terminal, you can enable http proxy and then Copy Http Proxy Shell Command and then past to Terminal,then you are good to go. If you have been using Shadowsocks, we can only apologize and recommend using other protocols we have to offer. Most people using Shadowsocks would get a better connection using other available protocols like OpenVPN, or WireGuard.The protocol grew popular in China thanks to its ability to evade the Great Wall of China. It is another advantage Shadowsocks has over regular proxy servers. It is primarily a TCP-oriented protocol but works on UDP. #SHADOWSOCKS PROTOCOL FREE#All of our other protocols work just fine in those regions. Shadowsocks works with other types of traffic, not just HTTP, and unlike most proxy services, it uses encryption and authentication. Shadowsocks for Windows Shadowsocks for Windows is a free and open source, high-performance secured socks5 proxy designed. However, almost none of our customers that connect to servers near restrictive regions (most of our users choose the fastest server option) use the Shadowsocks protocol.
The program replaced the mailbox hierarchy view with "live views" and a Bayesian engine you were expected to train, giving you more views onto the mail. Initial versions (back when Opera called it M2) eschewed folders completely. At first, you never quite know what's going on. What confounds newcomers to Opera Mail is its database-like approach. I found that all these email programs - Live Mail - the Bat, occasionally even Thunderbird - suffered from nanny Microsoft sizing them up for a premature kill. After a while a dialog box pops up asking you if you want to terminate the stuttering process - which was actually doing fine until Windows decided to "help". #CREATE RULES IN OPERA MAIL WINDOWS 7#(As an aside, Vista and Vista 2010 Windows 7 seem to have this annoying habit of turning a stuttering, but still functioning program into a system-wide seizure - the screen dramatically fades into white then back again, the conventional effect Hollywood uses when the main character is hit over head by a wrench, and passes out. In version 9.5, it got a significant overhaul which saw the back end revamped, resulting in much improved performance: there are no stutters even with multiple accounts, or multi-gigabyte mail archives. The numbers in the table specifies the first browser version that fully supports. It's not as if Opera has been completely neglecting Opera Mail. The font-face rule is supported in Edge, Chrome, Firefox, Safari, and Opera. In mitigation he pointed out that Thunderbird had been neglected for years too, even though the functionality was there, inherited from the old Netscape. He agrees the landscape is pretty dire now: "Email clients have gone away."īut making it a mass market product was a question of resources, and right now Opera's desktop browser team is going pell mell in a Javascript benchmark war with Google. But you can't accuse von Tetzchner of not eating his own dog food: he said he personally has between 20GB and 30GB of email in his own Opera Mail email archive, going back over 15 years. In fact, I'm entirely certain Opera isn't going to start promoting Mail all of a sudden. Was now the time to spring this on an unsuspecting world? Opera has been hiding an amazing email program for seven years now, in a place nobody would think of looking: in a web browser. Meeting Opera founder and chairman Jon von Tetzchner last week I nagged him, as I almost always do, about the secret Opera mail project. #CREATE RULES IN OPERA MAIL MAC#That leaves one of the best kept secrets on all three platforms Windows, Mac and Linux uncovered.
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Some users have wanted centralized, computer-based control and management of Synchronization and backup and done using Roomie's native support for DropBox. Synchronize that setup across any iPad, iPhone, or iPod touch so that everyĭevice (including your spouse’s!) always has the latest updates. You receive a call on your iPhone, and get vibration-feedback when pressingīest of all, once you’ve set up Roomie to control your system, you can IPhone or iPad’s volume button, the ability to auto-mute your audio system if Powering your device off when it should be on and vice versa.Īlso get some unique features such as the ability to control volume with your Roomie also keeps track of your devices’ power stateĪutomatically-even if your device doesn’t have two-way feedback or discreet onīut huge feature that can save your sanity by preventing activities from You would expect in a premium universal remote, Roomie supports advanced macrosĪnd granular customization of components including timing between commands and Integration with iTunes, AirPlay, SONOS, TiVo, Roku, and DirectTV and an integrated TV program guide to see what’s playing. #ITUNES REMOTE REVIEWS SERIAL#You’ll even get two-way, liveįeedback from supported IP-based and serial devices showing you current volume, Serial as well, you just need to buy a small piece of hardware. It has built-in support for thousands of devices and over 125,000Īutomatic discovery, configuration, and control of most of modern IP-based home Universal remote users feel right at home. #ITUNES REMOTE REVIEWS ANDROID#Remote is an iOS-only app (sorry Android users) that will make hard-core, You’ve been asking any of these questions, then an app called Roomie Remote HowĬool would it be if you could control all your gear, including lighting,ĭrapery, and home surveillance, from an iPhone or iPad in a slick, powerful, Universal remote app? Then I can just use my iPhone or iPad.” But why stop withĪ basic universal remote, your iOS device is an incredibly power device. But, being the brainiac you are, your next thought was Love those touch screen remotes, but those things are really expensive!” Well, you’re right. Good universal remote, preferably with a cool, customizable touch screen. #ITUNES REMOTE REVIEWS HOW TO#If our beloved spouse can’t figure out how to “watch TV” in ourĮither way, if you’re serious about your home theater, then you need a Some of us, nothing makes a man cave statement like a slick universal The nutrients and bioactive components in cherries support their preventive health benefits. So what are the benefits of cherries, and what makes them so beneficial? Take another dose of tart cherry juice the following morning to maximize the performance-enhancing benefits it has to offer.Cherries are popular because of their sweet and juicy characteristics, but more and more research suggests that cherries are extremely beneficial to your health too. As a bonus, mix in 20g of the slow digesting protein casein to boost your protein synthesis while you sleep. 6 Tart cherry juice tastes great and is a nice bedtime snack. Research has verified the benefits of both tart cherry concentrate and the powdered form. To give your immune system a boost, drink one fluid oz of tart cherry juice concentrate twice per day for seven days prior to and on the day of the event or workout. Tart cherry juice can reduce the incidence of upper respiratory tract symptoms 5 and keep you healthy and ready to smash your goals. It is crushing to finish off your last big training block before a peak race and then get sick. Hard bouts of training and racing are well known to depress your immune system. To reduce muscle pain, drink one fluid oz of tart cherry juice concentrate twice per day for seven days prior to and on the day of the event or workout. Consumption of tart cherry juice before and after intense training and racing can reduce muscle pain without any health damaging side-effects. NSAIDs, however, have adverse side-effects and can cause problematic and dangerous gastrointestinal, renal, and cardiovascular issues. I know some athletes who pop a couple of Ibuprofen as a habit before every training session. Tart cherry juice side effects professional#Training and racing at a serious amateur or professional level sometimes hurts! It is tempting to use NSAIDs pre-race to ward off the sensation of muscle pain which may make you suffer more than you want and slow down. To reduce joint pain, drink one fluid oz of tart cherry juice concentrate twice per day. It is always more fun to train when your joints don’t hurt which encourages you to get out there and push hard. Drinking tart cherry juice can significantly reduce joint pain without the side effects often associated with arthritis medications and NSAIDs. Sore joints will slow you down by reducing training volume and intensity. 3 Inflammation related joint issues such as osteoarthritis are common in master’s athletes. Tart cherries contain a high concentration of anthocyanin, a flavonoid that has similar anti-inflammatory properties to non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. To get better sleep, drink one fluid oz of tart cherry juice concentrate diluted in 5 to 8 fl oz of cold water, 30 minutes before bed. As a bonus, tart cherry juice has been shown to do even more for athletes by reducing inflammation, reducing muscle damage, increasing cycling economy and maximum strength following high-intensity exercise. Increasing sleep will enhance recovery and make you happier. Add a dose of tart cherry juice to your bedtime snack to sleep like a baby. 1 This improves sleep duration and quality. Studies have shown consumption of tart cherry juice concentrate increases melatonin levels. Tart Montmorency cherries contain melatonin, a phytochemical critical in regulating sleep cycles. This can be hard to come by for athletes with a non-stop lifestyle and high stress schedules. The latest darling is tart cherry juice and scientists are verifying it is a superfood that has performance-enhancing benefits for endurance athletes.Īthletes focused on fast recovery, sharp mental processing and high training motivation, need top quality sleep. Research is proving that we benefit from choosing whole natural foods time and time again. Whole foods contain many compounds which may act synergistically to provide an overall effect beyond that which a manufactured supplement or product can match. The human body has many biochemical pathways and mechanisms we have yet to fully understand. The latest revolution in the sports nutrition and supplement industry is the revelation that real whole foods can work as well as or better than pharmaceutical drugs or manufactured supplements, without the negative side effects. Coach Lynda Wallenfels explains the many benefits of tart cherry juice and gives dosage recommendations for maximum effectiveness. The Benefits of Tart Cherry Juice for Endurance AthletesĮndurance athletes are constantly searching for new methods that will help them to train more effectively. In the eventuality that you are on the lookout for a user-friendly and straightforward utility that enables you to access and view videos, pictures and other multimedia files on your computer, then perhaps Voya Media Free could come in handy. A tool for viewing various multimedia files #Vooya player software#Therefore, you can use the app to check out multiplex audio, video and other streams that you commonly can access via professional software solutions.Ī further useful feature is the rotate, particularly if you intend to employ the tool for closely examining photos that you took via your smartphone or perhaps digital sports cameras. The highlight of the application stems from the fact that it supports a plethora of file formats along with a vast majority of modern codecs, including but not limited to ALAC, DTS, TrueHD, XviD, DivX, H.264, OGM, WebP, so on and so forth.Įven though it does not work with Bluray or DVD formats, it is worth mentioning that the utility is capable of playing single M2TS files. Enables you to access various multimedia files Unfortunately, you can access only one multimedia file at a time and it would have been useful if you could load and explore an entire directory. The plugin mechanism is based on standard shared libraries loaded at runtime, so plugins can be written in any language suitable for creating shared libraries, notably C/C++, Rust or Objective-C. 11k Followers, 197 Following, 1,129 Posts - See Instagram photos and videos from Vooya (thevooyager) thevooyager. When opened, the app appears to scan or analyze the file, although you should know that the Free utility does not come with metadata or file management capabilities. vooya is a raw video sequencer player for Windows, macOS and Linux and has, beginning with version 1.6, an open plugin API. To put it simply, accessing a file entails you click on an inconspicuous button located in the bottom left region of the UI. Upon launch, you are welcomed by an appealing interface, but that can be slightly confusing unless you have used this application in the past. The installation is fast, forthright and does not require any special attention from your part. See the changelog for details, as well as some screenshots.Voya Media Free is a small piece of software designed to help you browse and explore multimedia files that you store on your computer. #Vooya player mp4#Floating point raw data image sequences Magnifier, pixel-exact view Diff View OpenEXR DPX player Radiance HDR TGA,TIFF, JPG, PNG, BMP y4m (YUV4MPEG) AVI (raw, mjpeg) MOV / ProRes / MP4 (H.264) Fast & Smart Endian Swap CLI pipe support Arbitrary bit depths One-File-Per-Frame sequences Timecode File format cache and format detection Plugin API Large File Support Playlists HDR Evaluation Mode Macroblocks overlay (AVC/HEVC/etc.) Brightness, Contrast, Gamma, Exposure HEVC CTU and PU indices Drag and Drop Drawing Annotations Side-by-Side, YesNo, Normal diff Advanced Deinterlacing Channel stepping Synchronized Playing PSNR, SSIM, MSE VMAF Histogram Offline conversion Deinterlacing Rotation Mirroring Reversal Extraction Fully scriptable CLI macOS, Linux and Windows Freeware on Linux Windows, macOS and Linux, and has a variety of features which makes working with raw data easier: #Vooya player download#is also available for download from Download vooya player, Download vooya. Oh and - yes, vooya can play MOV, MP4 and ProRes seamlessly. Windows XP Windows M3u8 Media Player free download - Windows Media Player. wazzamoss ReemAbulleil Sarcastic At the end of the day, the government of a state represent the inhabitants. Vooya is a YUV player and a generic raw data player – videoĭata that is uncompressed and containerless, most commonly used in scientific environments.īesides, vooya plays DPX, TIFF, OpenEXR and Radiance (HDR) image sequences. Vooya is a player for raw (uncompressed and containerless) video data, most commonly used in scientific and broadcast/OTT environments, and has a variety of. The retention feels great on the mags, the major drawback is that due to the KYWI the mag pouch doesn't collapse.
GoatTracker allows fine control of many of the SID chips capabilities. Browse on the folder examples and load the file everlasting.sng. Be sure that 1x mode is active (if you are in 2x mode, just click on the 2 in the 2x label and you will go back in 1x mode. Songs can be developed on Windows, MacOS, or Linux, and then exported for playback on original C64/C128 hardware. Start Goattracker, by double-clicking the Goat icon. Hope the approval process doesn't take too long. GoatTracker (and GoatTracker Stereo) GoatTrackeris a SID trackerthat runs on modern platforms. .xz: Cross-platform C64 music tracker: gobby-1:0.6.: A collaborative text editor: .xz: OCR (Optical Character Recognition) program, which converts scanned images of text back to text files: .xz: Encrypted overlay filesystem written. The SID used in the SidTracker video can be downloaded from here. Supports emulated output via Dag Lems reSID engine, the HardSID soundcard or CatWeasel MK3. On the iPad I'm using Modizer to listen to SIDs and it uses the same engine but lacks the filter-distortion plug-in, so the 6581 doesn't sound as 'warm' as with the proper filter distortion emulation. This is a crossplatform C64 music editor. It supports emulated output via the software reSID engine, the HardSID soundcard, or the Catweasel (MK3/MK4) controller card, and produces songs in its own format (.SNG). The app happens to be open-source and is still working good under Mac OS X 10.10.3 and hasn't been update in very long time, the sync towards HVSC collection still works too goattracker - C64 music editor SYNOPSIS goattracker DESCRIPTION This manual page documents briefly the goattracker command. (Just enable 'best accuracy' and enable the 'filter distortion plug-in' for proper 6581 emulation). #C64 goattracker for macI've been listening to SIDs with SidPlay for Mac for many many years and it's SID-Emulation (6581 & 8580 + various revisions) is as close to a real C64 I've ever heard.(My C64 broke down long time ago). I'm pretty sure these guys know what they are doing when it comes to SID-Emulation |
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